Loop-mediated isothermal amplification for the rapid, sensitive, and specific detection of the O9 group of Salmonella in chickens

Vet Microbiol. 2008 Nov 25;132(1-2):197-204. doi: 10.1016/j.vetmic.2008.04.029. Epub 2008 Apr 30.

Abstract

In the present study, the loop-mediated isothermal amplification (LAMP) assay was developed to amplify the fragments of the O9 Salmonella-specific insertion element and evaluated in the laboratory for its potential use in a field situation, such as poultry farms. Among the bacteria tested, a positive reaction was observed only for 128 strains of 6 serovars of the O9 group Salmonella, such as Enteritidis (SE) and Pullorum. The detection limit of the LAMP assay was 10(3)CFU/ml, which was more sensitive than that of the polymerase chain reaction (PCR) assay with the same target gene (10(6)CFU/ml). The final results were obtained within 30 min for the LAMP assay, while the PCR assay needed a total of 120 min. When the LAMP assay was applied to the enrichment broth mixed with cecal dropping samples either spiked with SE in vitro or excreted by SE-inoculated hens, the results were comparable to those of the conventional plating method including 2 separate enrichments. In conclusion, the LAMP assay developed in the present study is an effective method for the specific detection of the O9 group Salmonella serovars, including SE.

MeSH terms

  • Animals
  • Bacteriological Techniques / veterinary
  • Chickens*
  • Feces / microbiology
  • Nucleic Acid Amplification Techniques
  • Poultry Diseases / diagnosis*
  • Poultry Diseases / microbiology
  • Salmonella / classification*
  • Salmonella / isolation & purification*
  • Salmonella Infections, Animal / diagnosis*
  • Salmonella Infections, Animal / microbiology
  • Sensitivity and Specificity