Abstract
Structural maintenance of chromosomes (SMC) proteins form the cohesin and condensin complexes and play important roles in sister chromatid pairing, chromosome segregation, and transcriptional regulation. Two papers in Nature Genetics now show that SMC-like proteins also participate in epigenetic processes such as X inactivation in mammals and RNA-directed DNA methylation in plants.
MeSH terms
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Adenosine Triphosphatases / chemistry
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Adenosine Triphosphatases / metabolism*
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Cell Cycle Proteins / chemistry
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Cell Cycle Proteins / metabolism*
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Chromatids / genetics
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Chromosomal Proteins, Non-Histone / chemistry
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Chromosomal Proteins, Non-Histone / metabolism*
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Cohesins
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DNA Methylation
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DNA, Plant / metabolism
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / metabolism*
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Epigenesis, Genetic*
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Gene Silencing*
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Genes, Plant
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Models, Genetic
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Multiprotein Complexes / chemistry
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Multiprotein Complexes / metabolism*
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RNA / genetics
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RNA / metabolism*
Substances
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Cell Cycle Proteins
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Chromosomal Proteins, Non-Histone
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DNA, Plant
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DNA-Binding Proteins
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Multiprotein Complexes
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condensin complexes
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RNA
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Adenosine Triphosphatases