Lack of ciprofloxacin ototoxicity after repeated ototopical application

J Claes; P J Govaerts; P H Van de Heyning; S Peeters

doi:10.1128/AAC.35.5.1014

Lack of ciprofloxacin ototoxicity after repeated ototopical application

Antimicrob Agents Chemother. 1991 May;35(5):1014-6. doi: 10.1128/AAC.35.5.1014.

Authors

J Claes¹, P J Govaerts, P H Van de Heyning, S Peeters

Affiliation

¹ Department of Otorhinolaryngology, University of Antwerp, Belgium.

Abstract

The possible side effects of ototopically applied ciprofloxacin on inner ear function were investigated. The hearing function of pigmented guinea pigs was evaluated by daily frequency-specific evoked response audiometry after repeated application of the drug to both ears. Ciprofloxacin appeared to have no statistically significant effect on the hearing thresholds of the experimental animals.

MeSH terms

Administration, Topical
Animals
Ciprofloxacin / administration & dosage
Ciprofloxacin / adverse effects*
Ear, Inner / drug effects*
Evoked Potentials, Auditory / drug effects
Female
Guinea Pigs
Hearing Disorders / chemically induced*
Male
Sensory Thresholds / drug effects

Substances

Ciprofloxacin