Abstract
The RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Blotting, Northern
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Cell Proliferation
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Chromosomes, Human, Pair 6 / genetics
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Disease Models, Animal*
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Genes, Tumor Suppressor / physiology*
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Genetic Therapy*
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Humans
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Melanoma, Experimental / genetics
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Melanoma, Experimental / pathology
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Melanoma, Experimental / therapy*
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Mice
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Mice, Nude
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Ribonucleases / genetics*
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Tumor Cells, Cultured
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Tumor Suppressor Proteins / genetics*
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Xenograft Model Antitumor Assays
Substances
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RNA, Messenger
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Tumor Suppressor Proteins
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Ribonucleases
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RNASET2 protein, human