Abstract
A convenient synthetic method was reported for the preparation of N-phthaloyl dehydroamino acid esters from easily accessible vinyl bromides (or vinyl tosylate) and potassium phthalimide. Rh-catalyzed asymmetric hydrogenation of these substrates with TangPhos gave the products with good to excellent enantioselectivities (up to 99% ee).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Esters
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Hydrogenation
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Molecular Structure
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Phthalic Acids / chemistry*
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Rhodium / chemistry*
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Stereoisomerism
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Vinyl Compounds / chemistry
Substances
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Amino Acids
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Esters
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Phthalic Acids
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Vinyl Compounds
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Rhodium