Delayed hematological recovery following autologous transplantation utilizing peripheral blood stem cells harvested after treatment with arsenic trioxide

Toshimitsu Ueki; Kazuteru Ohashi; Minako Jinta; Yoshiki Okuyama; Kiyoshi Hiruma; Hideki Akiyama; Hisashi Sakamaki

doi:10.1007/s12253-008-9049-5

Delayed hematological recovery following autologous transplantation utilizing peripheral blood stem cells harvested after treatment with arsenic trioxide

Pathol Oncol Res. 2008 Dec;14(4):387-90. doi: 10.1007/s12253-008-9049-5. Epub 2008 Jun 14.

Authors

Toshimitsu Ueki¹, Kazuteru Ohashi, Minako Jinta, Yoshiki Okuyama, Kiyoshi Hiruma, Hideki Akiyama, Hisashi Sakamaki

Affiliation

¹ Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Bunkyo-ku, Tokyo, 113-8677, Japan.

PMID: 18553162
DOI: 10.1007/s12253-008-9049-5

Abstract

We describe herein two cases of delayed hematological recovery (DHR) following autologous peripheral blood stem cell transplantation (auto-PBSCT) using cells harvested during second molecular remission after treatment with arsenic trioxide (As(2)O(3)). Current therapeutic strategies with As(2)O(3) plus auto-PBSCT might be hampered by potential mechanisms of DHR. Our observations highlight the need for study of the real effects of As(2)O(3) on the kinetics of normal hematopoietic engraftment following auto-PBSCT.

Publication types

Case Reports

MeSH terms

Adult
Antineoplastic Agents / adverse effects*
Arsenic Trioxide
Arsenicals / adverse effects*
Hematopoietic Stem Cell Mobilization
Hematopoietic Stem Cells / drug effects*
Humans
Leukemia, Promyelocytic, Acute / physiopathology
Leukemia, Promyelocytic, Acute / therapy*
Male
Middle Aged
Neoplasm Recurrence, Local / physiopathology
Neoplasm Recurrence, Local / therapy
Oxides / adverse effects*
Peripheral Blood Stem Cell Transplantation*
Reverse Transcriptase Polymerase Chain Reaction
Transplantation, Autologous

Substances

Antineoplastic Agents
Arsenicals
Oxides
Arsenic Trioxide