Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter----q15

S Minoshima; M Amagai; J Kudoh; R Fukuyama; T Hashimoto; T Nishikawa; N Shimizu

doi:10.1159/000133108

Localization of the human gene for 230-kDal bullous pemphigoid autoantigen (BPAG1) to chromosome 6pter----q15

Cytogenet Cell Genet. 1991;57(1):30-2. doi: 10.1159/000133108.

Authors

S Minoshima¹, M Amagai, J Kudoh, R Fukuyama, T Hashimoto, T Nishikawa, N Shimizu

Affiliation

¹ Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan.

PMID: 1855390
DOI: 10.1159/000133108

Abstract

Chromosome mapping of the human gene encoding the 230-kDal autoantigen of an autoimmune skin disease, bullous pemphigoid, was performed using flow-sorted human chromosomes of cells of normal karyotype and cells carrying a reciprocal translocation t(6;16)(q15;q24). The cDNA of the autoantigen hybridized with intact chromosome 6 and translocation chromosome 6p- (6pter----q15::16q24----qter). The gene (BPA230) was located to the chromosome region 6pter----q15.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Autoantigens / genetics*
Carrier Proteins*
Chromosome Mapping
Chromosomes, Human, Pair 6*
Collagen Type XVII
Collagen*
Cytoskeletal Proteins*
DNA / genetics
Dystonin
Humans
Karyotyping
Mice
Nerve Tissue Proteins*
Non-Fibrillar Collagens*
Nucleic Acid Hybridization
Pemphigoid, Bullous / immunology*
Translocation, Genetic

Substances

Autoantigens
Carrier Proteins
Cytoskeletal Proteins
DST protein, human
Dst protein, mouse
Dystonin
Nerve Tissue Proteins
Non-Fibrillar Collagens
Collagen
DNA