Abstract
Selective bradykinin (BK) B 1 receptor antagonists could be novel therapeutic agents for the treatment of pain and inflammation. Elucidation of the structure activity relationships of the structurally novel HTS lead compound 1 provided potent hBK B 1 receptor antagonists with excellent receptor occupancy in the CNS of hBK B 1 transgenic rats.
MeSH terms
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Amines / chemistry*
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Animals
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Benzophenones / chemical synthesis
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Benzophenones / chemistry*
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Benzophenones / pharmacology*
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Bradykinin B1 Receptor Antagonists*
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Cell Line
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Dogs
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Humans
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Molecular Structure
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Rats
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Receptor, Bradykinin B1 / metabolism
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Structure-Activity Relationship
Substances
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Amines
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Benzophenones
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Bradykinin B1 Receptor Antagonists
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Receptor, Bradykinin B1