Abstract
A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC(50) 7.83 microM for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Chemistry, Pharmaceutical / methods
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Drug Design
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Inhibitory Concentration 50
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Isoflavones / chemistry*
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Mice
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Microglia / drug effects
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Microglia / metabolism*
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Models, Chemical
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Nitric Oxide / chemistry*
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Nitric Oxide Synthase Type II / metabolism*
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Quinolones / chemistry
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Temperature
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Tetrazolium Salts / pharmacology
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Thiazoles / pharmacology
Substances
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Isoflavones
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Quinolones
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Tetrazolium Salts
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Thiazoles
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Nitric Oxide
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Nitric Oxide Synthase Type II
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thiazolyl blue