Abstract
From October 1999 to September 2006, 29 carbapenem-resistant isolates of Acinetobacter baumannii were collected consecutively from patients hospitalized in different wards of the University Hospital in Pleven, Bulgaria. The bla(OXA-23) gene, associated with the upstream-located ISAba1, was identified as the mechanism responsible for carbapenem resistance in all isolates. The isolates belonged to two different clonal groups, indicating a sustained hospital outbreak. This study demonstrates both the epidemic potential of carbapenem-resistant A. baumannii and its longevity in the hospital environment.
MeSH terms
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Acinetobacter Infections / epidemiology*
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Acinetobacter Infections / microbiology
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Acinetobacter baumannii / classification
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / enzymology
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Acinetobacter baumannii / genetics*
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Anti-Bacterial Agents / pharmacology
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Bacterial Typing Techniques
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Bulgaria / epidemiology
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Carbapenems / pharmacology*
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Cross Infection / epidemiology*
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Cross Infection / microbiology
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DNA, Bacterial / isolation & purification
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Disease Outbreaks*
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Drug Resistance, Multiple, Bacterial
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Female
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Genes, Bacterial
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Genotype
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Hospitals, University
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Humans
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Infant, Newborn
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Male
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Microbial Sensitivity Tests
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Middle Aged
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Polymerase Chain Reaction
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beta-Lactam Resistance*
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Carbapenems
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DNA, Bacterial
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beta-lactamase OXA-23
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beta-Lactamases