Synthesis of an ent-halimanolide from ent-halimic acid

Molecules. 2008 May 9;13(5):1120-34. doi: 10.3390/molecules13051120.

Abstract

An efficient synthesis of ent-halimanolide 2 (15,16-epoxy-12-oxo-ent-halima- 5(10),13(16),14-trien-18,2beta-olide), from ent-halimic acid has been achieved, corroborating the structure of the natural compound and establishing its absolute configuration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diterpenes / chemical synthesis*
  • Diterpenes / chemistry
  • Euphorbiaceae / chemistry

Substances

  • Diterpenes
  • ent-halimanolide 2
  • ent-halimic acid