To be an expatriate can be a very rewarding experience. Nevertheless, it requires a great ability of adaptation to a new environment. The living and professional conditions may be very demanding. They can have an influence on the physical and mental health. The basic and cumulative stress should be prevented by a good preparation before departure, a thorough follow-up during the expatriation and upon return. The expatriate, the family doctor and the employer play an important role during the whole period of expatriation. Their close collaboration permits an ideal management of possible stress related problems.