High rate of intestinal colonization with extended-spectrum-beta-lactamase-producing organisms in household contacts of infected community patients

J Clin Microbiol. 2008 Aug;46(8):2796-9. doi: 10.1128/JCM.01008-08. Epub 2008 Jun 18.

Abstract

Fecal carriage of extended-spectrum-beta-lactamase (ESBL)-producing organisms was detected in 70% of index cases of patients (n = 40) with community-acquired infections due to ESBL producers and reached 16.7% in household contacts (n = 54). A total of 66% of ESBL-producing organisms from index cases were indistinguishable from isolates from household contacts by pulsed-field gel electrophoresis. Patients with community infections and members of their households represent a reservoir for ESBL producers, increasing dispersal of resistance in healthy people.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Bacteria / classification*
  • Bacteria / enzymology*
  • Bacteria / isolation & purification
  • Bacterial Infections / microbiology
  • Bacterial Infections / transmission*
  • Bacterial Typing Techniques
  • Carrier State / microbiology*
  • Child
  • Child, Preschool
  • Community-Acquired Infections / microbiology
  • Community-Acquired Infections / transmission*
  • DNA Fingerprinting
  • Electrophoresis, Gel, Pulsed-Field
  • Family Characteristics
  • Family Health*
  • Feces / microbiology
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Molecular Epidemiology
  • beta-Lactamases / analysis*

Substances

  • beta-Lactamases