Concise synthesis of a heptasaccharide antigen found in the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990

Rajib Panchadhayee; Anup Kumar Misra

doi:10.1007/s10719-008-9142-8

Concise synthesis of a heptasaccharide antigen found in the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990

Glycoconj J. 2008 Dec;25(9):817-26. doi: 10.1007/s10719-008-9142-8. Epub 2008 Jun 21.

Authors

Rajib Panchadhayee¹, Anup Kumar Misra

Affiliation

¹ Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow, 226 001, India.

PMID: 18568400
DOI: 10.1007/s10719-008-9142-8

Abstract

A straight forward synthesis of a heptasaccharide part of the cell-wall lipopolysaccharide of Mycobacterium gordonae strain 990, known to have antigenicity, has been achieved in excellent yield. Judicious choice of protecting groups in the intermediates played a significant role throughout the synthesis. Most of the intermediate steps furnished satisfactory yield.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antigens, Bacterial / chemistry
Antigens, Bacterial / immunology*
Carbohydrate Conformation
Carbohydrate Sequence
Cell Wall / chemistry*
Lipopolysaccharides / chemistry*
Molecular Sequence Data
Nontuberculous Mycobacteria / immunology*
Oligosaccharides / chemical synthesis*
Oligosaccharides / chemistry

Substances

Antigens, Bacterial
Lipopolysaccharides
Oligosaccharides