Abstract
The spliceosome is both compositionally and conformationally dynamic. Each transition along the splicing pathway presents an opportunity for progression, pausing, or discard, allowing splice site choice to be regulated throughout both the assembly and catalytic phases of the reaction.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Adenosine Triphosphatases / genetics
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Adenosine Triphosphatases / metabolism
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Alternative Splicing
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Animals
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Base Sequence
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Humans
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Models, Genetic
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Mutation*
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Nucleic Acid Conformation
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RNA / chemistry
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RNA / genetics*
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RNA Splicing / genetics*
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RNA, Messenger / genetics
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Spliceosomes / genetics*
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Spliceosomes / metabolism
Substances
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RNA, Messenger
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RNA
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Adenosine Triphosphatases