In vivo selection of an Escherichia coli isolate highly resistant to ciprofloxacin and ceftazidime: role of a 4-bp duplication in acrR and ampC overexpression

Int J Antimicrob Agents. 2008 Aug;32(2):196-8. doi: 10.1016/j.ijantimicag.2008.04.001. Epub 2008 Jun 20.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics*
  • Bacterial Proteins / metabolism
  • Ceftazidime / pharmacology*
  • Ciprofloxacin / pharmacology*
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Escherichia coli / drug effects*
  • Escherichia coli / genetics
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / microbiology
  • Escherichia coli Proteins / genetics*
  • Escherichia coli Proteins / metabolism
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Pyelonephritis / drug therapy
  • Pyelonephritis / microbiology
  • Repressor Proteins / genetics*
  • Repressor Proteins / metabolism
  • Selection, Genetic
  • Sequence Analysis, DNA
  • Up-Regulation
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism

Substances

  • AcrR protein, E coli
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Escherichia coli Proteins
  • Repressor Proteins
  • Ciprofloxacin
  • Ceftazidime
  • AmpC beta-lactamases
  • beta-Lactamases

Associated data

  • GENBANK/EU021290