Objective: To study whether VEGF expression is associated with clinical characteristics such as gender, age, aggressive, stage, B-symptoms and complete remission (CR) rate of patients with non-Hodgkin's lymphoma.
Methods: Expression of VEGF had been tested in 98 biopsy samples by immunohistochemical method as LSAB. Chi-Square test was used to do the statistical analysis of ratio comparison between different groups.
Results: Comparing VEGF positive rates grouped by sexuality, age, aggressive grade or stage, the results suggested no significant correlation between them. VEGF positive rate of patients accompanied with B-symptoms was 86.1%, versus 51.6% of patients B-symptoms free, P = 0.001. Among 94 patients, their responses to chemotherapy could be estimated, delaminated by B-symptoms, and the CR rate of VEGF negative group was significantly higher, P values were 0.000 and 0.028.
Conclusions: Expression of VEGF is associated with B-symptoms and poor response to chemotherapy in patients with non-Hodgkin's lymphoma, there was not any relationship to have been found between VEGF expression and sexuality, age, aggressive grade, stage.