Enantioselective Claisen rearrangements with a hydrogen-bond donor catalyst

J Am Chem Soc. 2008 Jul 23;130(29):9228-9. doi: 10.1021/ja803370x. Epub 2008 Jun 25.

Abstract

N,N'-Diphenylguanidinium ion associated with the noncoordinating BArF counterion is shown to be an effective catalyst for the [3,3]-sigmatropic rearrangement of a variety of substituted allyl vinyl ethers. Highly enantioselective catalytic Claisen rearrangements of ester-substituted allyl vinyl ethers are then documented using a new C2-symmetric guanidinium ion derivative.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Allyl Compounds / chemistry*
  • Catalysis
  • Esters / chemistry
  • Ethers / chemistry*
  • Guanidine / chemistry*
  • Hydrogen Bonding
  • Models, Molecular
  • Stereoisomerism
  • Vinyl Compounds / chemistry*

Substances

  • Allyl Compounds
  • Esters
  • Ethers
  • Vinyl Compounds
  • vinyl ether
  • Guanidine