Modularity in the genetic disease-phenotype network

FEBS Lett. 2008 Jul 23;582(17):2549-54. doi: 10.1016/j.febslet.2008.06.023. Epub 2008 Jun 26.

Abstract

Similar disease phenotypes are engendered as a result of the modular nature of gene networks; thus we hypothesized that all human genetic disease phenotypes appear in similar modular styles. Network representations of phenotypes make it possible to explore this hypothesis. We investigated the modularity of a network of genetic disease phenotypes. We computationally extracted phenotype modules and found that the modularity is well correlated with a physiological classification of human diseases. We also found correlations between the modularity and functional genomics as well as its connection to drug-target associations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Regulatory Networks*
  • Genetic Diseases, Inborn / classification*
  • Genetic Diseases, Inborn / genetics*
  • Genomics
  • Genotype
  • Humans
  • Phenotype*