Soft tissue sarcoma in the setting of chronic cutaneous graft versus host disease after allogenic bone marrow transplantation

Cancer Invest. 2008 Jul;26(6):638-41. doi: 10.1080/07357900701787991.

Abstract

Second primary cancers are approximately 2.1-2.8 times more common in survivors of bone marrow transplant than in the age-matched general population. We describe a patient who developed high-grade sarcoma in two disparate sites that were clinically involved by chronic cutaneous graft versus host disease (GVHD). This occurred 3.5 years after bone marrow transplant for acute myelogenous leukemia (AML). This suggests that malignant sarcomas may develop in the setting of chronic GVHD, and close surveillance of GVHD-related nodules is warranted.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy, Fine-Needle
  • Bone Marrow Transplantation / adverse effects*
  • Chemotherapy, Adjuvant
  • Chronic Disease
  • Graft vs Host Disease / complications*
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / pathology
  • Humans
  • Leukemia, Myeloid, Acute / surgery*
  • Male
  • Neoadjuvant Therapy
  • Neoplasms, Second Primary*
  • Radiotherapy, Adjuvant
  • Sarcoma / etiology*
  • Sarcoma / pathology
  • Sarcoma / surgery
  • Sarcoma / therapy
  • Skin Diseases / complications*
  • Skin Diseases / etiology
  • Skin Diseases / pathology
  • Soft Tissue Neoplasms / etiology*
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / therapy
  • Time Factors
  • Tomography, X-Ray Computed
  • Transplantation, Homologous
  • Treatment Outcome