Abstract
A 71-year-old man with advanced left renal cell carcinoma (lymph node involvement and vena cava thrombus) was submitted to 6 months of neoadjuvant treatment with sorafenib before open radical nephrectomy. After sorafenib treatment and before surgery a new CT scan confirmed the presence of a 9.0 cm in diameter solid mass in the left kidney but a reduction in thrombus extension, limited to the left renal vein. At histological examination after radical nephrectomy, over 90% of the renal mass was substituted by necrotic tissue.
2008 S. Karger AG, Basel.
MeSH terms
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Administration, Oral
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Aged
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Antineoplastic Agents / administration & dosage
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Benzenesulfonates / administration & dosage*
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Carcinoma, Renal Cell / pathology
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Carcinoma, Renal Cell / therapy*
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Chemotherapy, Adjuvant
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Follow-Up Studies
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Humans
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Kidney Neoplasms / pathology
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Kidney Neoplasms / therapy*
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Male
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Neoadjuvant Therapy
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Neoplasm Invasiveness / pathology
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Neoplasm Staging
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Neoplastic Cells, Circulating / drug effects
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Neoplastic Cells, Circulating / pathology*
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Nephrectomy* / methods
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Niacinamide / analogs & derivatives
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Phenylurea Compounds
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Pyridines / administration & dosage*
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Risk Assessment
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Sorafenib
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Treatment Outcome
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Vena Cava, Inferior / pathology*
Substances
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Antineoplastic Agents
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Benzenesulfonates
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Phenylurea Compounds
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Pyridines
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Niacinamide
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Sorafenib