Abstract
From among 15 human cathelicidin LL-37-derived peptides, FK-13 was identified as the smallest peptide active against human immunodeficiency virus (HIV) and GI-20 had the highest therapeutic index, which was twice that of LL-37. BMAP-18, which is derived from bovine cathelicidin BMAP-27, possessed a therapeutic index similar to that of GI-20. Peptide sequence order, helical structures, and aromatic residues are important in HIV inhibition.
MeSH terms
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Amino Acid Sequence
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Animals
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Anti-HIV Agents* / chemical synthesis
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Anti-HIV Agents* / chemistry
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Anti-HIV Agents* / pharmacology
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Antimicrobial Cationic Peptides / chemical synthesis
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Antimicrobial Cationic Peptides / chemistry*
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Antimicrobial Cationic Peptides / metabolism
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Antimicrobial Cationic Peptides / pharmacology
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Cathelicidins
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Cattle
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HIV Infections / virology
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HIV-1 / drug effects*
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Humans
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Microbial Sensitivity Tests / methods
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Structure-Activity Relationship
Substances
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Anti-HIV Agents
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Antimicrobial Cationic Peptides
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Cathelicidins