Abstract
New helper lipids, possessing an imidazole polar head, have been synthesized and included in formulations for transfection assays; these new helper lipids can improve the transfection by a factor of up to 100 compared to the use of DOPE as co-lipid.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / chemistry
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Amides / metabolism*
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Cell Line
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Drug Design*
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Humans
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Imidazoles / chemistry*
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Lipid Bilayers / chemistry
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Phosphatidylethanolamines / metabolism
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Phosphoramides
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Phosphoric Acids / chemical synthesis*
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Phosphoric Acids / chemistry
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Phosphoric Acids / metabolism*
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Transfection / methods*
Substances
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1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine
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Amides
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Imidazoles
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Lipid Bilayers
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Phosphatidylethanolamines
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Phosphoramides
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Phosphoric Acids
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phosphoramide