Abstract
Anorexia-cachexia syndrome is a very common symptom observed in individuals affected by chronic inflammatory diseases. The present study was designed to address the possible involvement of the inducible microsomal prostaglandin E synthase-1 (mPGES-1) in the hypopaghia observed during these pathological states. To this end, we used a model of cancer-induced anorexia and we report here that despite the absence of up-regulation of the mPGES-1 enzyme within the brain during anorexia-cachexia syndrome, mPGES-1 knock-out mice exhibit resistance to tumor-induced anorexia and maintain their body mass.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anorexia / enzymology*
-
Anorexia / etiology
-
Blotting, Western
-
Brain / enzymology*
-
Brain / immunology
-
Cachexia / etiology
-
Cytokines / biosynthesis
-
Inflammation / immunology
-
Inflammation / metabolism
-
Inflammation / physiopathology
-
Intramolecular Oxidoreductases / genetics
-
Intramolecular Oxidoreductases / metabolism*
-
Male
-
Mice
-
Mice, Knockout
-
Neoplasms / complications*
-
Prostaglandin-E Synthases
-
Reverse Transcriptase Polymerase Chain Reaction
-
Up-Regulation
Substances
-
Cytokines
-
Intramolecular Oxidoreductases
-
Prostaglandin-E Synthases
-
Ptges protein, mouse