BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method

So Hee Kim; So Yeon Kim; Byung Wook Eun; Won Joon Yoo; Kyoung Un Park; Eun Hwa Choi; Eui-Chong Kim; Hoan Jong Lee

doi:10.1016/j.vaccine.2008.06.004

BCG osteomyelitis caused by the BCG Tokyo strain and confirmed by molecular method

Vaccine. 2008 Aug 12;26(34):4379-81. doi: 10.1016/j.vaccine.2008.06.004. Epub 2008 Jun 20.

Authors

So Hee Kim¹, So Yeon Kim, Byung Wook Eun, Won Joon Yoo, Kyoung Un Park, Eun Hwa Choi, Eui-Chong Kim, Hoan Jong Lee

Affiliation

¹ Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.

PMID: 18603342
DOI: 10.1016/j.vaccine.2008.06.004

Abstract

Bacille Calmette-Guérin (BCG) osteitis is a rare complication of BCG vaccination. We describe two cases of BCG osteomyelitis developed in Korean infants who were given multipuncture BCG vaccination. The cultures of bone curettage specimens grew mycobacteria. The isolates were identified as BCG Tokyo strains by the deletion of the region of difference 1 (RD1) and characterization of RD8 and RD14 using the multiplex polymerase chain reaction.

Publication types

Case Reports

MeSH terms

DNA, Bacterial / genetics
Female
Humans
Infant
Korea
Male
Mycobacterium Infections / diagnosis*
Mycobacterium Infections / microbiology
Mycobacterium bovis / genetics
Mycobacterium bovis / isolation & purification*
Osteomyelitis / microbiology*
Polymerase Chain Reaction / methods
Tuberculosis Vaccines / adverse effects*

Substances

DNA, Bacterial
Tuberculosis Vaccines