Rearrangement of N,N-di-tert-butoxycarbonylpyridin-4-amines and formation of polyfunctional pyridines

Yahua Liu; Qiang Ding; Xu Wu

doi:10.1021/jo800854d

Rearrangement of N,N-di-tert-butoxycarbonylpyridin-4-amines and formation of polyfunctional pyridines

J Org Chem. 2008 Aug 1;73(15):6025-8. doi: 10.1021/jo800854d. Epub 2008 Jul 9.

Authors

Yahua Liu¹, Qiang Ding, Xu Wu

Affiliation

¹ Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA.

PMID: 18610981
DOI: 10.1021/jo800854d

Abstract

N, N-Di-tert-butoxycarbonylpyridin-4-amines were found to be rearranged to tert-butyl 4-(tert-butoxycarbonylamino)nicotinates by treatment with LDA in THF.

MeSH terms

Amines / chemical synthesis*
Amines / chemistry
Carboxylic Acids / chemistry*
Molecular Structure
Oxygen / chemistry*
Pyridines / chemical synthesis*
Pyridines / chemistry

Substances

Amines
Carboxylic Acids
Pyridines
Oxygen