Successful use of the anti-CD25 antibody daclizumab in an adult patient with hemophagocytic lymphohistiocytosis

Am J Hematol. 2008 Sep;83(9):747-9. doi: 10.1002/ajh.21236.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe inflammatory disorder marked by abnormal cytotoxic T and natural killer cell activity, resulting in impaired clearance of pathogen, excessive cytokine production, and continued immune system activation. Soluble IL-2 receptor (sIL-2R or sCD25) is typically elevated in HLH and can serve as a marker of disease activity, although its role in the pathophysiology of the disease is unclear. Here we present a case of an adult patient with steroid-dependent HLH who was treated successfully with daclizumab, a monoclonal anti-CD25 antibody, allowing successful withdrawal of steroid therapy without an increase in symptoms.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers
  • Cyclophosphamide / administration & dosage
  • Cyclosporine / therapeutic use
  • Daclizumab
  • Doxorubicin / administration & dosage
  • Ferritins / blood
  • Humans
  • Immunoglobulin G / therapeutic use*
  • Immunosuppressive Agents / therapeutic use*
  • Interleukin-2 Receptor alpha Subunit / antagonists & inhibitors*
  • Interleukin-2 Receptor alpha Subunit / immunology
  • Killer Cells, Natural / immunology
  • Lymphohistiocytosis, Hemophagocytic / complications
  • Lymphohistiocytosis, Hemophagocytic / drug therapy*
  • Lymphoma, Large-Cell, Anaplastic / complications
  • Lymphoma, Large-Cell, Anaplastic / drug therapy
  • Male
  • Middle Aged
  • Prednisone / administration & dosage
  • Recurrence
  • T-Lymphocyte Subsets / chemistry
  • T-Lymphocyte Subsets / immunology
  • Vincristine / administration & dosage

Substances

  • Adrenal Cortex Hormones
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Biomarkers
  • Immunoglobulin G
  • Immunosuppressive Agents
  • Interleukin-2 Receptor alpha Subunit
  • Vincristine
  • Doxorubicin
  • Cyclosporine
  • Cyclophosphamide
  • Ferritins
  • Daclizumab
  • Prednisone

Supplementary concepts

  • CHOP protocol