Ear, nose and throat manifestations of Behçet's disease: a review

J Laryngol Otol. 2008 Dec;122(12):1279-83. doi: 10.1017/S0022215108002703. Epub 2008 Jul 11.

Abstract

Objective: To review Behçet's disease and to describe its clinical features in the head, neck and upper respiratory tract.

Method: A literature review was undertaken, following a Medline search of publications over a 30-year period, and utilising the expert knowledge of one of the authors (RJM) with a specialist interest in Behçet's disease.

Results: Twenty-seven articles with ENT relevance were obtained. Otorhinolaryngological manifestations included symptoms and signs in the mouth, nose, sinus, larynx and ear.

Conclusion: Behçet's disease is usually considered to be a condition affecting the oral cavity, eyes and genitals. This article shows that most patients will also exhibit other ENT symptoms, hearing loss in particular. Indeed, Behçet's disease may present with features other than the classic triad of symptoms. Raised awareness of the clinical features within the head and neck region will hopefully enable early diagnosis and treatment of this potentially serious condition.

Publication types

  • Review

MeSH terms

  • Behcet Syndrome / complications*
  • Behcet Syndrome / diagnosis
  • Behcet Syndrome / drug therapy
  • Behcet Syndrome / epidemiology
  • Female
  • HLA-B Antigens / drug effects
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Male
  • Oral Ulcer / drug therapy
  • Oral Ulcer / etiology
  • Oral Ulcer / pathology
  • Otorhinolaryngologic Diseases / drug therapy
  • Otorhinolaryngologic Diseases / epidemiology
  • Otorhinolaryngologic Diseases / etiology*
  • Otorhinolaryngologic Diseases / pathology
  • Respiration Disorders / drug therapy
  • Respiration Disorders / epidemiology
  • Respiration Disorders / etiology*
  • Steroids / therapeutic use
  • Ulcer / drug therapy
  • Ulcer / epidemiology
  • Ulcer / etiology*
  • Ulcer / pathology

Substances

  • HLA-B Antigens
  • Immunosuppressive Agents
  • Steroids