Abstract
Four new cadinane sesquiterpenes (1- 4), including a dimeric cadinane derivative (2) and a peroxide cadinane analogue (3), have been isolated from the leaves of Eupatorium adenophorum. Their structures including absolute configurations were determined on the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 showed in vitro cytotoxicity against the HCT-8, Bel-7402, and A2780 cancer cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ageratina / chemistry*
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Cell Line, Tumor
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Structure
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Plant Leaves / chemistry*
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Polycyclic Sesquiterpenes
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
Substances
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Polycyclic Sesquiterpenes
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Sesquiterpenes
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cadinane