Abstract
The dried seeds of XANTHIUM STRUMARIUM (Asteraceae) are used after thorough stir-frying as an ingredient in traditional Chinese medicines for relieving allergy. Two new compounds, xanthialdehyde ( 2) and (-)-xanthienopyran ( 7), as well as 26 known compounds were isolated in the present study. The structures of the isolates were elucidated by spectroscopic methods. Among them, compound 7 exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl- L-methionyl- L-leucyl- L-phenylalanine, with an IC50 value of 1.72 microg/mL.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aldehydes / chemistry
-
Aldehydes / isolation & purification*
-
Antineoplastic Agents, Phytogenic / isolation & purification
-
Cell Line, Tumor
-
Drugs, Chinese Herbal / chemistry
-
Humans
-
Inhibitory Concentration 50
-
Molecular Structure
-
Neutrophils / drug effects*
-
Neutrophils / metabolism
-
Pyrans / chemistry
-
Pyrans / isolation & purification
-
Pyrans / pharmacology*
-
Seeds / chemistry
-
Superoxides / metabolism*
-
Xanthines / chemistry
-
Xanthines / isolation & purification*
-
Xanthines / pharmacology*
-
Xanthium / chemistry*
Substances
-
Aldehydes
-
Antineoplastic Agents, Phytogenic
-
Drugs, Chinese Herbal
-
Pyrans
-
Xanthines
-
xanthialdehyde
-
xanthienopyran
-
Superoxides