Abstract
We report here a comparative study of the anti-hepatitis C virus (HCV) activities of selected (i) nucleoside polymerase, (ii) nonnucleoside polymerase, (iii) alpha,gamma-diketo acid polymerase, (iv) NS3 protease, and (v) helicase inhibitors, as well as (vi) cyclophilin binding molecules and (vii) alpha 2b interferon in four different HCV genotype 1b replicon systems.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / pharmacology*
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Cell Line, Tumor
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DNA Helicases / antagonists & inhibitors
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Enzyme Inhibitors / pharmacology*
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Hepacivirus / drug effects*
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Hepacivirus / enzymology
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Hepacivirus / genetics
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Humans
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Microbial Sensitivity Tests / methods
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Protease Inhibitors / pharmacology*
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RNA-Dependent RNA Polymerase / antagonists & inhibitors
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Replicon / drug effects
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Replicon / genetics
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Enzyme Inhibitors
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Protease Inhibitors
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RNA-Dependent RNA Polymerase
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DNA Helicases