Efficient synthesis of sulfonyl azides from sulfonamides

Org Lett. 2008 Aug 21;10(16):3385-8. doi: 10.1021/ol8011088. Epub 2008 Jul 17.

Abstract

Triflyl azide serves as an efficient diazo transfer reagent in this first direct synthesis of sulfonyl azides from readily available and stable sulfonamides. The process is experimentally simple, mild, and high-yielding. Sulfonyl azides participate in various catalytic transformations providing rapid access to diversely functionalized sulfonamide derivatives in good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azides / chemical synthesis*
  • Azides / chemistry
  • Molecular Structure
  • Stereoisomerism
  • Sulfonamides / chemistry*
  • Sulfones / chemical synthesis*
  • Sulfones / chemistry

Substances

  • Azides
  • Sulfonamides
  • Sulfones