Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole

Traffic. 2008 Sep;9(10):1665-80. doi: 10.1111/j.1600-0854.2008.00793.x. Epub 2008 Jul 9.

Abstract

A critical step in infection by the apicomplexan parasite Toxoplasma gondii is the formation of a membrane-bound compartment within which the parasite proliferates. This process relies on a set of secretory organelles that discharge their contents into the host cell upon invasion. Among these organelles, the dense granules are specialized in the export of transmembrane (TM) GRA proteins, which are major components of the mature parasitophorous vacuole (PV) membrane. How eukaryotic pathogens export and sort membrane-bound proteins destined for the host cell is still poorly understood at the mechanistic level. In this study, we show that soluble trafficking of the PV-targeted GRA5 TM protein is parasite specific: when expressed in mammalian cells, GRA5 is targeted to the plasma membrane and behaves as an integral membrane protein with a type I toplogy. We also demonstrate the dual role of the GRA5 N-terminal ectodomain, which is sufficient to prevent membrane integration within the parasite and is essential for both sorting and post-secretory membrane insertion into the vacuolar membrane. These results contrast with the general rule that states that information contained within the cytoplasmic tail and/or the TM domain of integral membrane proteins dictates their cellular localization. They also highlight the diversity of sorting mechanisms that leads to the specialization of secretory processes uniquely adapted to intracellular parasitism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Protozoan / genetics
  • Antigens, Protozoan / metabolism*
  • Antigens, Protozoan / physiology
  • Cell Line
  • Cytoplasmic Granules / physiology
  • Cytoplasmic Granules / ultrastructure
  • Fibroblasts / metabolism
  • Fibroblasts / parasitology
  • Fibroblasts / physiology
  • Fibroblasts / ultrastructure
  • Host-Parasite Interactions / physiology*
  • Humans
  • Intracellular Membranes / metabolism
  • Intracellular Membranes / ultrastructure
  • Microscopy, Fluorescence
  • Protein Transport / physiology
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism*
  • Protozoan Proteins / physiology
  • Secretory Pathway
  • Toxoplasma* / metabolism
  • Toxoplasma* / pathogenicity
  • Toxoplasma* / physiology
  • Transfection
  • Vacuoles / metabolism
  • Vacuoles / parasitology*
  • Vacuoles / physiology
  • Vacuoles / ultrastructure

Substances

  • Antigens, Protozoan
  • GRA5 protein, Toxoplasma gondii
  • Protozoan Proteins