With a little help from their friends: interleukin-21, T cells, and B cells

Jonathan S Silver; Christopher A Hunter

doi:10.1016/j.immuni.2008.06.005

With a little help from their friends: interleukin-21, T cells, and B cells

Immunity. 2008 Jul 18;29(1):7-9. doi: 10.1016/j.immuni.2008.06.005.

Authors

Jonathan S Silver¹, Christopher A Hunter

Affiliation

¹ Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavillion, 380 South University Avenue, Philadelphia, PA 19104-4539, USA.

PMID: 18631451
DOI: 10.1016/j.immuni.2008.06.005

Abstract

T follicular cells help B cells generate high-affinity antibodies. Two papers in this issue of Immunity (Nurieva et al., 2008, and Vogelzang et al., 2008) have identified a role for interleukin-21 in the development of these specialized cells and highlight questions about how this dedicated population is generated.

Publication types

Comment

MeSH terms

Animals
B-Lymphocytes / immunology*
Germinal Center / cytology
Germinal Center / immunology
Interleukin-21
Interleukins / immunology*
Lymphocyte Activation / immunology
Lymphocyte Cooperation / immunology*
T-Lymphocyte Subsets / immunology*
T-Lymphocytes, Helper-Inducer / immunology*

Substances

Interleukins
Interleukin-21