Angiogenesis is a process of creating new vessels which is necessary in pathogenesis of many diseases and disorders like inflammatory or malignancies. A lot of markers, both stimulating and inhibiting can influence on this process. Knowledge about angiogenesis and its markers, e.g. Vascular Endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF) can be used in diagnosis and treatment of diseases like malignancies. For these reasons summary of these processes seems to be very important and valid.