Abstract
We report on two patients, successfully treated by the combination therapy of S-1 and 24-h infusion of cisplatin (CDDP), who were initially diagnosed with unresectable stage 4 advanced gastric cancer. Each patient had a very good clinical response and underwent curative gastrectomy after completion of 14 and 10 courses of S-1/CDDP chemotherapy, respectively. A microscopically detailed examination of surgically obtained specimens showed the complete disappearance of malignant cells in the two cases. S-1/CDDP combination therapy can, therefore, be highly active in incurable advanced gastric carcinoma.
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / secondary
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Adenocarcinoma / surgery
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Adult
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Aged
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Aged, 80 and over
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bone Neoplasms / drug therapy
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Bone Neoplasms / secondary
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Cisplatin / administration & dosage
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Drug Combinations
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Female
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Humans
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Infusions, Intravenous
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Liver Neoplasms / drug therapy
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Liver Neoplasms / secondary
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Lymphatic Metastasis
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Male
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Middle Aged
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Oxonic Acid / administration & dosage
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Peritoneal Neoplasms / drug therapy
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Peritoneal Neoplasms / secondary
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Prognosis
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Remission Induction
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Stomach Neoplasms / surgery
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Survival Rate
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Tegafur / administration & dosage
Substances
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Drug Combinations
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S 1 (combination)
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Tegafur
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Oxonic Acid
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Cisplatin