Abstract
Various new chiral hydroxysulfonamide ligands (3a-3n, 4a-4d) were prepared. Compounds 3a, 3g, 3i, 3k-3n, 4a-4d could accelerate the reaction and reduce reaction time, and 3a, 3g, 3i, 3k-3n catalyzed the reaction without titanium. The results obtained were promising in terms of yields and enantiomeric excesses (3k up to 85% ee, 4a up to 83% ee).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry
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Acetylene / analogs & derivatives*
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Acetylene / pharmacology
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Alcohols / chemistry
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Catalysis
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Chemistry, Organic / methods
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Ketones / metabolism*
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Ligands
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Models, Chemical
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Stereoisomerism
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Sulfonamides / chemistry*
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Temperature
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Time Factors
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Titanium / chemistry*
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Zinc / chemistry*
Substances
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Acetophenones
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Alcohols
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Ketones
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Ligands
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Sulfonamides
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phenylacetylene
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Titanium
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Zinc
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Acetylene
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acetophenone