Pulmonary infiltrates with eosinophilia due to naproxen

Jpn J Med. 1991 Jan-Feb;30(1):32-4. doi: 10.2169/internalmedicine1962.30.32.

Abstract

An increasing number of drugs have been implicated in the etiology of eosinophilic pneumonia characterized by the development of pulmonary infiltrates, and peripheral blood eosinophilia. Naproxen is a commonly used nonsteroidal anti-inflammatory drug which may be added to the growing list of pharmacologic agents associated with infiltrative pulmonary lesions. A case of eosinophilic pneumonia induced by Naproxen is described. The results of TBLB, a lymphocyte stimulation test, and a challenge test supported this diagnosis.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Drug Hypersensitivity / etiology*
  • Drug Hypersensitivity / pathology
  • Female
  • Humans
  • Lung / pathology
  • Lymphocyte Activation / drug effects
  • Naproxen / adverse effects*
  • Naproxen / pharmacology
  • Naproxen / therapeutic use
  • Osteoarthritis / complications
  • Osteoarthritis / drug therapy
  • Pulmonary Eosinophilia / chemically induced*
  • Pulmonary Eosinophilia / pathology

Substances

  • Naproxen