Abstract
A series of novel N,O-psiconucleosides has been prepared in both enantiomeric forms by resolution of an advanced racemic synthetic intermediate using (R)-N-phenylpantolactam as a chiral resolution agent. The absolute configuration of all of these compounds has been unequivocally established by chemical correlation with the novel (R)- or (S)-1-methyl-5-phenylpyrrolidine-2,3-dione, prepared from the known (R)- and (S)-1-methyl-5-phenylpyrrolidin-2-one, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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Animals
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Antiviral Agents / chemical synthesis
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Antiviral Agents / pharmacology*
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DNA Viruses / drug effects*
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DNA Viruses / growth & development
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Esterification
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Humans
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Lactams / chemistry*
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Magnetic Resonance Spectroscopy
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Pyrrolidines / chemistry
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RNA Viruses / drug effects*
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RNA Viruses / growth & development
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Stereoisomerism
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X-Ray Diffraction
Substances
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Antiviral Agents
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Lactams
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Pyrrolidines
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pantolactone
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4-Butyrolactone