A multidisciplinary approach is necessary to determine the optimal treatment for individual patients with liver metastases. The benefits of surgical resection and systemic chemotherapy are well established Surgical resection is the only treatment that can ensure long-term survival and cure in some cases. However, only a minority of patients with liver metastases are amenable to surgery and recurrences are still observed after resection in two-thirds of patients. Efforts are being made to increase the number of candidates for surgery and to reduce the risk of post-operative recurrence, notably by means of perioperative chemotherapy and new surgical techniques.