Abstract
The relationship between the structure of new semisynthetic derivatives of doxorubicin, daunorubicin, and carminomycin and their ability to inhibit topoisomerase 1 were studied. The new derivatives inhibit the activity of topoisomerase 1 at low concentrations, induce the death of K-562 leukemia cells in culture, and produce an antitumor effect in experimental animals with P388 leukemia.
MeSH terms
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Animals
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Carubicin / analogs & derivatives*
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Carubicin / chemistry*
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Carubicin / pharmacology
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Daunorubicin / analogs & derivatives*
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Daunorubicin / chemistry*
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Daunorubicin / pharmacology
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Doxorubicin / analogs & derivatives*
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Doxorubicin / chemistry*
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Doxorubicin / pharmacology
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Drug Screening Assays, Antitumor
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Humans
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K562 Cells
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Leukemia P388 / drug therapy
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Mice
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Structure-Activity Relationship
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Topoisomerase I Inhibitors*
Substances
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Topoisomerase I Inhibitors
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Doxorubicin
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Carubicin
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Daunorubicin