The CorA Mg2+ channel is required for the virulence of Salmonella enterica serovar typhimurium

J Bacteriol. 2008 Oct;190(19):6517-23. doi: 10.1128/JB.00772-08. Epub 2008 Aug 1.

Abstract

CorA is the primary Mg(2+) channel in Salmonella enterica serovar Typhimurium. A corA mutant is attenuated in mice and defective for invasion of and replication within epithelial cells. Microarray studies show that several virulence effectors are repressed in a corA mutant strain, which ultimately manifests itself as a decrease in virulence.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Bacterial Proteins / physiology
  • Blotting, Western
  • Caco-2 Cells
  • Cation Transport Proteins / genetics
  • Cation Transport Proteins / metabolism*
  • Cation Transport Proteins / physiology
  • Humans
  • Magnesium / metabolism*
  • Mice
  • Mice, Inbred BALB C
  • Mutation
  • Oligonucleotide Array Sequence Analysis
  • Salmonella Infections, Animal / microbiology
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / metabolism*
  • Salmonella typhimurium / pathogenicity
  • Virulence / genetics

Substances

  • Bacterial Proteins
  • Cation Transport Proteins
  • CorA protein, Salmonella
  • Magnesium