[Autologous hematopoietic stem cell transplantation followed by oral bexarotene in a patient with advanced mycosis fungoides]

Actas Dermosifiliogr. 2008 Sep;99(7):560-4.
[Article in Spanish]

Abstract

We describe the case of a 17-year-old patient with rapidly progressing and aggressive mycosis fungoides, with multiple cutaneous tumors and large cell transformation. She was initially treated with 3 cycles of high-dose chemotherapy with mega-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) without response, leading to the decision to undertake autologous hematopoietic stem cell transplantation. Partial remission of the disease was achieved with this treatment and subsequent introduction of oral bexarotene led to complete remission, which has been maintained for more than 3 years with good tolerance of oral therapy. We discuss the advantages and disadvantages of autologous hematopoietic stem cell transplantation and the use of oral bexarotene.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bexarotene
  • Busulfan / administration & dosage
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Doxorubicin / administration & dosage
  • Etoposide / administration & dosage
  • Female
  • Humans
  • Interferon alpha-2
  • Interferon-alpha / therapeutic use
  • Mechlorethamine / administration & dosage
  • Methylprednisolone / administration & dosage
  • Mycosis Fungoides / drug therapy
  • Mycosis Fungoides / pathology
  • Mycosis Fungoides / radiotherapy
  • Mycosis Fungoides / surgery*
  • PUVA Therapy
  • Peripheral Blood Stem Cell Transplantation*
  • Prednisone / administration & dosage
  • Recombinant Proteins
  • Remission Induction
  • Tetrahydronaphthalenes / therapeutic use*
  • Transplantation, Autologous
  • Vincristine / administration & dosage

Substances

  • Antineoplastic Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
  • Tetrahydronaphthalenes
  • Cytarabine
  • Mechlorethamine
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Bexarotene
  • Busulfan
  • Cisplatin
  • Prednisone
  • Methylprednisolone

Supplementary concepts

  • BUCY-2 protocol
  • ESAP protocol