Abstract
In a recent paper in Nature Neuroscience, Jessberger et al. (2008) report that overexpression of ASCL1 (mash1) directs adult hippocampal progenitors to adopt an oligodendrocytic fate. The effect is specific to the hippocampal niche in vivo, indicating that cell-autonomous and niche-defined factors collaborate to instruct cell fate choices.
Publication types
-
Introductory Journal Article
MeSH terms
-
Adult
-
Animals
-
Basic Helix-Loop-Helix Transcription Factors / genetics
-
Basic Helix-Loop-Helix Transcription Factors / metabolism*
-
Cell Differentiation
-
Dentate Gyrus / cytology*
-
Dentate Gyrus / embryology
-
Dentate Gyrus / growth & development
-
Humans
-
Oligodendroglia / cytology*
-
Oligodendroglia / metabolism
-
Organogenesis / genetics*
-
Signal Transduction / genetics
-
Stem Cell Niche
-
Stem Cells / cytology
-
Stem Cells / metabolism
-
Transcriptional Activation / genetics*
Substances
-
ASCL1 protein, human
-
Basic Helix-Loop-Helix Transcription Factors