Exploiting cross-amyloid interactions to inhibit protein aggregation but not function: nanomolar affinity inhibition of insulin aggregation by an IAPP mimic

Angew Chem Int Ed Engl. 2008;47(37):7114-8. doi: 10.1002/anie.200801499.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Amyloid / antagonists & inhibitors*
  • Amyloid / chemistry
  • Amyloid / metabolism
  • Amyloid / pharmacology
  • Amyloid / toxicity
  • Cell Line, Tumor
  • Humans
  • Insulin / metabolism*
  • Molecular Mimicry*
  • Molecular Sequence Data

Substances

  • (N-Me)G24, (N-Me)I26-IAPP
  • Amyloid
  • Insulin