Formulating at acidic pH is a route to improve the chemical or biological stability and the performances of cosmeceuticals. Unfortunately, its potential is limited by the poor differentiation of available acidic agents, and by the risk of skin irritation. Recently, a perfluoropolyether phosphate was proposed to formulate acidic gels and emulsions, with advantages related with the specific active ingredient. The safety of these compositions, evaluated on volunteers, was the main objective of several studies. On the basis of these tests, and of its activity as O/W emulsifier, antimicrobial agent and oil repellent material, it can be asserted that perfluoropolyether phosphate widens the potential of acidic compositions regarding safety and functionality.