Abstract
Seminal plasma of men with spinal cord injury (SCI) contains high concentrations of cytokines. Neutralizing these target cytokines did not damage sperm DNA or sperm viability, indicating that this method may hold promise as a safe therapy for improving sperm motility in men with SCI.
Publication types
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal / pharmacology
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Cell Survival / physiology
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Cytokines / immunology
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DNA Fragmentation / drug effects
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Humans
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Infertility, Male / etiology
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Infertility, Male / therapy*
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Male
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Receptors, Cytokine / antagonists & inhibitors
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Reproductive Techniques, Assisted*
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Sodium Chloride / pharmacology
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Sperm Motility / drug effects
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Sperm Motility / physiology*
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Spermatozoa / physiology*
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Spinal Cord Injuries / complications
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Spinal Cord Injuries / physiopathology*
Substances
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Antibodies, Monoclonal
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Cytokines
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Receptors, Cytokine
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Sodium Chloride