During a planned, rapid deployment of a modified commercial CPOE product to units at an academic pediatric center, problems from users and staff were collected and entered in text format on a commercially available online problem tracking system. Content analysis of 278 collected text reports collected over 3 weeks after the 24-hour rollout period revealed several themes: center-specific implementation problems (45%), transfer-handoff-collaboration problems (14%), missing product functionalities (11%), inadequate training (11%), hardware problems (5%), password problems (4%) and human error (2%). This analysis may prove helpful in future deployments of CPOE in pediatric clinical environments.