Abstract
Metronidazole, which is used for the treatment of infections caused by anaerobic organisms, was evaluated in Mycobacterium tuberculosis-infected guinea pigs. M. tuberculosis can adapt to hypoxia, which is present in the primary lesions of infected guinea pigs. Metronidazole treatment (for 6 weeks at 100 mg/kg of body weight) resulted in no reduction in the bacillary burden and significantly worsened lesion inflammation.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antitubercular Agents / pharmacology*
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Colony Count, Microbial
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Female
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Guinea Pigs
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Isoniazid / pharmacology
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Lung / drug effects
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Lung / microbiology
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Lung / pathology
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Metronidazole / pharmacology*
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Mycobacterium tuberculosis / drug effects
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Mycobacterium tuberculosis / isolation & purification
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Pyrazinamide / pharmacology
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Rifampin / pharmacology
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Spleen / drug effects
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Spleen / microbiology
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Tuberculosis, Pulmonary / drug therapy*
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Tuberculosis, Pulmonary / microbiology
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Tuberculosis, Pulmonary / pathology
Substances
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Antitubercular Agents
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Metronidazole
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Pyrazinamide
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Isoniazid
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Rifampin