GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity

Cancer Biol Ther. 2008 Jul;7(7):1079. doi: 10.4161/cbt.7.7.6519. Epub 2008 Jun 27.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Apoptosis
  • Benzylisoquinolines / pharmacology*
  • Cell Line, Tumor
  • Cyclin D1 / metabolism
  • Cyclin-Dependent Kinase Inhibitor p27
  • Enzyme Inhibitors / pharmacology
  • Gene Expression Regulation
  • Glycogen Synthase Kinase 3 / metabolism*
  • Glycogen Synthase Kinase 3 beta
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Medicine, Chinese Traditional
  • Models, Biological
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Proto-Oncogene Proteins c-akt / metabolism*

Substances

  • Antineoplastic Agents
  • Benzylisoquinolines
  • CDKN1B protein, human
  • Enzyme Inhibitors
  • Intracellular Signaling Peptides and Proteins
  • Cyclin D1
  • Cyclin-Dependent Kinase Inhibitor p27
  • tetrandrine
  • Phosphatidylinositol 3-Kinases
  • GSK3B protein, human
  • Glycogen Synthase Kinase 3 beta
  • Proto-Oncogene Proteins c-akt
  • Glycogen Synthase Kinase 3